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Health & Longevity Carousels

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Clinical Review

Omega-3 Fatty Acids
& Systemic Inflammation

n = 2,843 patients 16 RCTs Median 12 weeks p < 0.001

A summary of evidence on EPA/DHA and inflammatory biomarker reduction in adults.

1 / 5

Key Finding

−32%

Reduction in serum CRP with EPA/DHA supplementation

C-reactive protein (CRP) is the most widely validated marker of systemic inflammation — and a strong independent predictor of cardiovascular events.

A meta-analysis of 16 RCTs found omega-3 reduced CRP by a mean of 32% across diverse populations.

Calder PC. (2017) Nutrients · PMID 28900017

2 / 5

Study Findings

Inflammatory marker reductions vs placebo

CRP

−32%

IL-6

−24%

TNF-α

−18%

hsCRP

−29%

0%−10%−20%−32%

% mean reduction vs placebo. EPA+DHA ≥2g/day, 8–24 week trials.

Calder PC. (2017) Nutrients · PMID 28900017 | Yates CM et al. (2014) · PMID 24739913

3 / 5

Claim vs Evidence

Common Claim

Fish oil supplements have no meaningful effect on inflammation — benefits come only from whole food sources.

Evidence

16 RCTs using purified EPA/DHA demonstrated consistent, statistically significant reductions in CRP, IL-6, and TNF-α independent of dietary fish intake.

Calder PC. (2017) Nutrients · PMID 28900017

4 / 5

Mechanism

How EPA/DHA suppresses inflammation

Eicosanoid Displacement

EPA competes with arachidonic acid at COX and LOX enzymes, shifting production toward less potent resolvins.

NF-κB Inhibition

DHA suppresses NF-κB translocation, reducing TNF-α, IL-6, and IL-1β transcription in macrophages.

Resolvin Synthesis

EPA and DHA are precursors to resolvins — pro-resolving mediators that terminate the inflammatory cascade.

Calder PC. (2015) Biochim Biophys Acta · PMID 25149823

5 / 5

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slidewell.io Omega-3 & systemic inflammation — here's what 16 peer-reviewed RCTs show 🧬

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Marcos Vidal

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✓30 carousels / month
✓Live PubMed search & citations
✓All 15 templates
✓PNG & PDF export
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Turn research
into carousels —
in minutes.

Built for health professionals who take content seriously.

Four steps from topic
to finished carousel.

Enter your topic

Pick a template

Choose your blocks

Generate & export

Grounded in science,
at every step.

Trusted by health creators
who care about accuracy.

Simple pricing.
No surprises.

Turn researchinto carousels —in minutes.

Built for health professionals who take content seriously.

Four steps from topicto finished carousel.

Enter your topic

Pick a template

Choose your blocks

Generate & export

Grounded in science,at every step.

Trusted by health creatorswho care about accuracy.

Simple pricing.No surprises.

Turn research
into carousels —
in minutes.

Four steps from topic
to finished carousel.

Grounded in science,
at every step.

Trusted by health creators
who care about accuracy.

Simple pricing.
No surprises.